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Left handed mode. I didn’t realise how much I liked it until no man’s sky. It moves the body of the character to the right hand side of the screen. So you can see the character holding the items in the left hand.
Most games just mirror the item into the other hand and that’s it.
https://www.protondb.com/ is worth a look. It shows the state of games using Proton and people list their tweaks to make games work. You can filter it to only show Nvidia GPU’s on PopOS as an example too. To find tweaks more applicable to your system.